ENTRY       EC 1.18.99.1
NAME        Hydrogenase
            Hydrogenlyase
CLASS       Oxidoreductases
            Acting on reduced ferredoxin as donor
            With H+ as acceptor
SYSNAME     Ferredoxin:H+ oxidoreductase
REACTION    2 Reduced ferredoxin + 2 H+ = 2 Oxidized ferredoxin + H2
SUBSTRATE   Reduced ferredoxin
            H+
            Hydrogen
PRODUCT     Oxidized ferredoxin
            H2
COFACTOR    Iron
            Nickel
            Sulfur
COMMENT     Contains iron-sulfur clusters, and enzymes from some sources
            contain nickel. Can use molecular hydrogen for the reduction of a
            variety of substances. Formerly EC 1.12.1.1, 1.12.7.1, 1.98.1.1
            and 1.18.3.1.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00680  Methane metabolism
MOTIF       PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00507  R-G-[LIVMF]-E-x(15)-[QE]-R-x-C-G-[LIVM]-C
            PS: PS00508  [FY]-D-P-C-[LIM]-[ASG]-C-x(2)-H
GENES       MJA: MJ0214 MJ0713
            MTH: MTH1063 MTH1072 MTH1193 MTH1287 MTH1396 MTH1525 MTH1627
                 MTH1634 MTH1649 MTH1722 MTH1795 MTH205 MTH313 MTH614 MTH711
                 MTH782 MTH783 MTH899
            ECO: b0972(hyaA) b0973(hyaB) b2718(hycH) b2720(hycF) b2721(hycE)
                 b2722(hycD) b2724(hycB) b2994(hybC) b2996(hybA)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.18.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.18.99.1
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