ENTRY       EC 1.17.4.1
NAME        Ribonucleoside-diphosphate reductase
            Ribonucleotide reductase
CLASS       Oxidoreductases
            Acting on -CH2- groups
            With a disulfide as acceptor
SYSNAME     2'-Deoxyribonucleoside-diphosphate:oxidized-thioredoxin
            2'-oxidoreductase
REACTION    2'-Deoxyribonucleoside diphosphate + Oxidized thioredoxin + H2O =
            Ribonucleoside diphosphate + Reduced thioredoxin
SUBSTRATE   2'-Deoxyribonucleoside diphosphate
            Oxidized thioredoxin
            H2O
PRODUCT     Ribonucleoside diphosphate
            Reduced thioredoxin
COFACTOR    Iron
            ATP
COMMENT     Requires ATP.  Nonheme diiron enzyme.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
DISEASE     MIM: 180390  Ribonucleotide reductase, M2 polypeptide
            MIM: 180410  Ribonucleotide reductase, M1 polypeptide
MOTIF       PS: PS00089  W-x(2)-[LF]-x(6,7)-G-[LIVM]-x-N-x(4)-A-x(2)-P
            PS: PS00368  E-x-[LIVTA]-H-x(3)-Y-x(2)-[LIVQ]-x(3)-[LIVMFY]-
                         [LIVMFYC]
GENES       MTH: MTH652
            ECO: b2234(nrdA) b2235(nrdB) b2675(nrdE) b2676(nrdF)
            HIN: HI1659(nrdA) HI1660(nrdB)
            HPY: HP0364(nrdB)
            BSU: nrdE(nrdA) nrdF yosP
            MGE: MG229(nrdF) MG231(nrdE)
            MPN: F10_orf339(nrdF) F10_orf721(nrdE)
            SYN: nrdF) slr0591(ECOLI_2609 slr1164(nrdA)
            SCE: YER070W(RNR1) YGR180C(RNR4) YIL066C(RNR3) YJL026W(RNR2)
            HSA: RRM1 RRM2(Hs.75319)
STRUCTURES  PDB: 1AFT  1XSM  1XIK  1RNR  1RLR  1RIB  1PFR  1MRR  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.17.4.1
            WIT (What Is There) Metabolic Reconstruction: 1.17.4.1
            SCOP (Structural Classificaion of Proteins): 1.17.4.1
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