ENTRY       EC 1.16.3.1
NAME        Ferroxidase
CLASS       Oxidoreductases
            Oxidizing metal ions
            With oxygen as acceptor
SYSNAME     Fe(II):oxygen oxidoreductase
REACTION    4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O
SUBSTRATE   Fe(II)
            H+
            O2
PRODUCT     Fe(III)
            H2O
COFACTOR    Copper
COMMENT     A multi-copper protein: ceruloplasmin from animals, rusticyanin in
            Thiobacillus ferroxidans.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DISEASE     MIM: 117700  Ceruloplasmin; [Hypoceruloplasminemia, hereditary]
                         (1); Hemosiderosis, systemic, due to aceruloplasminemia
                         (3)
MOTIF       PS: PS00079  G-x-[FYW]-x-[LIVMFYW]-x-[CST]-x(8)-G-[LM]-x(3)-
                         [LIVMFYW]
            PS: PS00080  H-C-H-x(3)-H-x(3)-[AG]-[LM]
GENES       HSA: CP(Hs.10735)
STRUCTURES  PDB: 1KCW  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.16.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.16.3.1
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