ENTRY       EC 1.14.99.9
NAME        Steroid 17alpha-monooxygenase
            Steroid 17alpha-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Steroid,hydrogen-donor:oxygen oxidoreductase
            (17-alpha-hydroxylating)
REACTION    Steroid + AH2 + O2 = 17-alpha-Hydroxysteroid + A + H2O
SUBSTRATE   Steroid
            AH2
            O2
PRODUCT     17-alpha-Hydroxysteroid
            A
            H2O
COFACTOR    NADPH
            NADH
            Heme
COMMENT     Requires NAD(P)H and P-450. Formarly EC 1.14.1.7 and 1.99.1.9.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
DISEASE     MIM: 202110  Cytochrome P450, subfamily XVII; steroid
                         17-alpha-hydroxylase; Adrenal hyperplasia, congenital,
                         due to 17-alpha-hydroxylase deficiency (3)
MOTIF       PS: PS00086  F-[SGNH]-x-[GD]-x-[RHPT]-x-C-[LIVMFAP]-[GAD]
GENES       HSA: CYP17(Hs.1363)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.99.9
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.9
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