ENTRY       EC 1.14.99.3
NAME        Heme oxygenase (decyclizing)
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Heme, hydrogen-donor:oxygen oxidoreductase (alpha-methylene-
            oxydizing, hydroxylating)
REACTION    Heme + 3 AH2 + 3 O2 = Biliverdin + Fe2+ + CO + 3 A + 3 H2O
SUBSTRATE   Heme
            AH2
            O2
PRODUCT     Biliverdin
            Fe2+
            CO
            A
            H2O
INHIBITOR   Zinc protoporphyrin-9
COFACTOR    NADH
            NADPH
COMMENT     Requires NAD(P)H and EC 1.6.2.4.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DISEASE     MIM: 141250  Heme oxygenase (decycling) 1
            MIM: 141251  Heme oxygenase (decycling) 2
MOTIF       PS: PS00593  L-L-V-A-H-A-Y-T-R
GENES       SYN: sll1184 sll1875
            HSA: HMOX1(Hs.75967) HMOX2(HO-2)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.3
///