ENTRY       EC 1.14.99.29
NAME        Deoxyhypusine monooxygenase
            Deoxyhypusine hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Deoxyhypusine, hydrogen-donor:oxygen oxidoreductase
            $ (2-hydroxylating)
REACTION    Protein N6-(4-Aminobutyl]-L-lysine + AH2 + O2 = Protein
            $ N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H2O
SUBSTRATE   Protein N6-(4-Aminobutyl]-L-lysine
            AH2
            O2
PRODUCT     Protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine
            A
            H2O
COMMENT     The enzyme catalyses the final step in the formation of the amino
            acid hypusine in the eukaryotic initiating factor 4D.
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.99.29
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.29
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