ENTRY       EC 1.14.99.18
NAME        N-Acetylneuraminate monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     N-Acetylneuraminate,hydrogen-donor:oxygen oxidoreductase
            $ (N-acetyl-hydroxylating)
REACTION    N-Acetylneuraminate + AH2 + O2 = N-Glycoloyl-neuraminate + A + H2O
SUBSTRATE   N-Acetylneuraminate
            AH2
            O2
            NADPH
            Ascorbate
PRODUCT     N-Glycoloyl-neuraminate
            A
            H2O
            NADP+
COFACTOR    Iron
COMMENT     Requires Fe2+. Either NADPH or ascorbate can act as AH2.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.99.18
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.18
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