ENTRY       EC 1.14.99.10
NAME        Steroid 21-monooxygenase
            Steroid 21-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
REACTION    Steroid + AH2 + O2 = 21-Hydroxysteroid + A + H2O
SUBSTRATE   Steroid
            AH2
            O2
PRODUCT     21-Hydroxysteroid
            A
            H2O
COFACTOR    Flavin
            Heme
COMMENT     An enzyme system involving a heme-thiolate protein (P-450) and
            flavoprotein. Formerly EC 1.14.1.8 and 1.99.1.11.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
DISEASE     MIM: 201910  Cytochrome P450, subfamily XXI; steroid
                         21-hydroxylase; Adrenal hyperplasia, congenital, due to
                         21-hydroxylase deficiency (3)
MOTIF       PS: PS00086  F-[SGNH]-x-[GD]-x-[RHPT]-x-C-[LIVMFAP]-[GAD]
GENES       HSA: CYP21(CYP21B)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.99.10
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.10
///