ENTRY       EC 1.14.99.1
NAME        Prostaglandin-endoperoxide synthase
            Prostaglandin synthase
            Prostaglandin G/H synthase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen
            oxidoreductase
REACTION    Arachidonate + AH2 + 2 O2 = Prostaglandin H2 + A + H2O
SUBSTRATE   Arachidonate
            AH2
            O2
PRODUCT     Prostaglandin H2
            A
            H2O
INHIBITOR   Aspirin
            Ibuprofen
            Diflunisal
            Diclofenac
            Fenprofen calcium
            Indomethacin
            Ketoprofen
            Meclofenamate sodium
            Mefenamic acid
            Naproxen
            Piroxicam
            Sulindac
            Tolmetin sodium
COMMENT     This enzyme acts both as a dioxygenase and as a peroxidase.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
DISEASE     MIM: 176805  Prostaglandin-endoperoxide synthase 1 (prostaglandin
                         G/H synthase and
            MIM: 600262  Prostaglandin-endoperoxide synthase 2 (prostaglandin
                         G/H synthase and
GENES       HSA: PTGS1(Hs.88474) PTGS2(COX-2)
STRUCTURES  PDB: 1PGF  1PGG  1PTH  1PGE  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.1
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