ENTRY       EC 1.14.18.1
NAME        Monophenol monooxygenase
            Tyrosinase
            Phenolase
            Monophenol oxidase
            Cresolase
SYSNAME     Monophenol,L-dopa:oxygen oxidoreductase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With another compound as one donor, and incorporation of one atom
            of oxygen
REACTION    L-Tyrosine + L-Dopa + O2 = L-Dopa + Dopaquinone + H2O
SUBSTRATE   L-Tyrosine
            L-Dopa
            Benzenediol
            O2
PRODUCT     L-Dopa
            Dopaquinone
            H2O
COFACTOR    Copper
COMMENT     A group of copper proteins that also catalyse the reaction of
            EC 1.10.3.1, if only benzenediols are available as substrate.
            (EC 1.10.3.1 Catechol oxidase)
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00740  Riboflavin metabolism
DISEASE     MIM: 203100  Tyrosinase; Albinism, oculocutaneous, type IA (3);
                         Waardenburg syndrome/ocular albinism, digenic, 103470
                         (3)
MOTIF       PS: PS00497  H-x(4)-F-[LIVMFTP]-x-[FW]-H-R-x(2)-[LM]-x(3)-E
            PS: PS00498  D-P-x-F-[LIVMFYW]-x(2)-H-x(3)-D
GENES       HSA: TYR(OCAIA)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.18.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.18.1
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