ENTRY       EC 1.14.17.3
NAME        Peptidylglycine monooxygenase
            Peptidylglycine 2-hydroxylase
            Peptidyl alpha-amidating enzyme
            Peptidyl alpha-amide synthetase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With ascorbate as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)
REACTION    Peptidylglycine + Ascorbate + O2 = Peptidyl(2-hydroxyglycine) +
            Dehydroascorbate + H2O
SUBSTRATE   Peptidylglycine
            Ascorbate
            O2
PRODUCT     Peptidyl(2-hydroxyglycine)
            Dehydroascorbate
            H2O
COFACTOR    Copper
COMMENT     A copper protein. Peptidylglycines with a neutral amino acid
            residue in the penultimate position are the best substrates
            for  the enzyme. The product is unstable and dismutates to
            glyoxylate and the corresponding desglycine peptide amide,
            a reaction catalyzed by EC 4.3.2.5.
            Involved in the final step of biosynthesis of alpha-melanotropin
            and related biologically active peptides.
DISEASE     MIM: 170270  Peptidylglycine alpha-amidating monooxygenase
MOTIF       PS: PS00084  H-H-M-x(2)-F-x-C
            PS: PS00085  H-x-F-x(4)-H-T-H-x(2)-G
GENES       HSA: PAM(Hs.83920)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.17.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.17.3
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