ENTRY       EC 1.14.17.1
NAME        Dopamine beta-monooxygenase
            Dopamine beta-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With ascorbate as one donor, and incorporation of one atom of
            oxygen
SYSNAME     3,4-Dihydroxyphenetylamine,ascorbate:oxygen oxidoreductase
            (beta-hydroxylating)
REACTION    3,4-Dihydroxyphenethylamine + Ascorbate + O2 = Noradrenaline +
            Dehydroascorbate + H2O
SUBSTRATE   3,4-Dihydroxyphenethylamine
            Ascorbate
            O2
PRODUCT     Noradrenaline
            Dehydroascorbate
            H2O
COFACTOR    Fumarate
            Copper
            PQQ
COMMENT     A copper protein. Stimulated by fumarate.  Formerly EC 1.14.2.1.
            PQQ: van der Meer,R.A., Jongejan,J.A., Duine,J.A. FEBS Lett. 231,
            303-307 (1988).
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DISEASE     MIM: 223360  Dopamine-beta-hydroxylase; Dopamine-beta-hydroxylase
                         deficiency (1)
MOTIF       PS: PS00084  H-H-M-x(2)-F-x-C
            PS: PS00085  H-x-F-x(4)-H-T-H-x(2)-G
GENES       HSA: DBH(Hs.2301)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.17.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.17.1
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