ENTRY       EC 1.14.16.4
NAME        Tryptophan 5-monooxygenase
            Tryptophan 5-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced pteridine as one donor, and incorporation of
            one atom of oxygen
SYSNAME     L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase
            (5-hydroxylating)
REACTION    L-Tryptophan + Tetrahydrobiopterin + O2 =
            5-Hydroxy-L-tryptophan + Dihydrobiopterin + H2O
SUBSTRATE   L-Tryptophan
            Tetrahydrobiopterin
            O2
PRODUCT     5-Hydroxy-L-tryptophan
            Dihydrobiopterin
            H2O
COFACTOR    Iron
COMMENT     Requires Fe2+. Activated by phosphorylation, catalysed by a
            Ca2+-activated protein kinase.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DISEASE     MIM: 191060  Tryptophan hydroxylase (tryptophan-5-monooxygenase)
MOTIF       PS: PS00367  P-D-x(2)-H-[DE]-[LI]-[LIVMF]-G-H-[LIVMC]-P
GENES       HSA: TPH(TPRH)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.16.4
            WIT (What Is There) Metabolic Reconstruction: 1.14.16.4
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