ENTRY       EC 1.14.16.2
NAME        Tyrosine 3-monooxygenase
            Tyrosine 3-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced pteridine as one donor, and incorporation of
            one atom of oxygen
SYSNAME     L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase
            (3-hydroxylating)
REACTION    L-Tyrosine + Tetrahydrobiopterin + O2 =
            3,4-Dihydroxy-L-phenylalanine + Dihydrobiopterin + H2O
SUBSTRATE   L-Tyrosine
            Tetrahydrobiopterin
            O2
PRODUCT     3,4-Dihydroxy-L-phenylalanine
            Dihydrobiopterin
            H2O
COFACTOR    Iron
COMMENT     Requires Fe2+. Activated by phosphorylation, catalysed by
            EC 2.7.1.128.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DISEASE     MIM: 191290  Tyrosine hydroxylase; Segawa syndrome, recessive (3)
MOTIF       PS: PS00367  P-D-x(2)-H-[DE]-[LI]-[LIVMF]-G-H-[LIVMC]-P
GENES       HSA: TH(Hs.89849)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.16.2
            WIT (What Is There) Metabolic Reconstruction: 1.14.16.2
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