ENTRY       EC 1.14.15.6
NAME        Cholesterol monooxygenase (side-chain-cleaving)
            Cholesterol desmolase
            Cytochrome P-450SCC
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With a reduced iron-sulfur protein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     Cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase
            (side-chain-cleaving)
REACTION    Cholesterol + Reduced adrenal ferredoxin + O2 = Pregnenolone +
            4-Methylpentanal + Oxidized adrenal ferredoxin + H2O
SUBSTRATE   Cholesterol
            Reduced adrenal ferredoxin
            O2
PRODUCT     Pregnenolone
            4-Methylpentanal
            Oxidized adrenal ferredoxin
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein. The reaction proceeds in three stages,
            with hydroxylation at C-20 and C-22 preceding scission of the
            side-chain at C-20.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
DISEASE     MIM: 118485  Cytochrome P450, subfamily XIA (cholesterol side chain
                         cleavage); Polycystic ovary syndrome with
                         hyperandrogenemia (2)
MOTIF       PS: PS00086  F-[SGNH]-x-[GD]-x-[RHPT]-x-C-[LIVMFAP]-[GAD]
GENES       HSA: CYP11A(Hs.76205)
STRUCTURES  PDB: 1SCC  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.15.6
            WIT (What Is There) Metabolic Reconstruction: 1.14.15.6
            SCOP (Structural Classificaion of Proteins): 1.14.15.6
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