ENTRY       EC 1.14.15.4
NAME        Steroid 11beta-monooxygenase
            Steroid 11beta-hydroxylase
            Steroid 11beta/18-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With a reduced iron-sulfur protein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     Steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase
            (11-hydroxylating)
REACTION    a Steroid + Reduced adrenal ferredoxin + O2 =
            an 11beta-Hydroxysteroid + Oxidized adrenal ferredoxin + H2O
SUBSTRATE   Steroid
            Reduced adrenal ferredoxin
            O2
            18-Hydroxycorticosterone
PRODUCT     11beta-Hydroxysteroid
            Oxidized adrenal ferredoxin
            H2O
            Aldosterone
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450). Also hydroxylates steroids at
            the 18-position, and converts 18-hydroxycorticosterone into
            aldosterone. Formerly EC 1.14.1.6 and 1.99.1.7.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
            PATH: MAP00150  Androgen and estrogen metabolism
DISEASE     MIM: 124080  Cytochrome P450, subfamily XIB, polypeptide-2; CMO II
                         deficiency (3)
            MIM: 202010  Cytochrome P450, subfamily XIB, polypeptide-1;
                         11-beta-hydroxylase;; Adrenal hyperplasia, congenital,
                         due to 11-beta-hydroxylase deficiency (3);
                         Aldosteronism, glucocorticoid-remediable (3)
MOTIF       PS: PS00086  F-[SGNH]-x-[GD]-x-[RHPT]-x-C-[LIVMFAP]-[GAD]
GENES       HSA: CYP11B1(CYP11B) CYP11B2(CYP11B)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.15.4
            WIT (What Is There) Metabolic Reconstruction: 1.14.15.4
///