ENTRY       EC 1.14.14.1
NAME        Unspecific monooxygenase
            Microsomal monooxygenase
            Xenobiotic monooxygenase
            Aryl-4-monooxygenase
            Aryl hydrocarbon hydroxylase
            Microsomal P-450
            Flavoprotein-linked monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced flavin or flavoprotein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     Substrate,reduced-flaboprotein:oxygen oxidoreductase
            (RH-hydroxylating or -epoxidizing)
REACTION    RH + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein
            + H2O
SUBSTRATE   RH
            Steroid
            Fatty acid
            Vitamin
            Prostaglandin
            Reduced flavoprotein
            O2
PRODUCT     ROH
            alpha-Hydroxy fatty acid
            Oxidized flavoprotein
            H2O
COFACTOR    Heme
COMMENT     A group of heme-thiolate proteins (P-450), acting on a wide range
            of substrates including many xenobiotics, steroids, fatty acids,
            vitamins and prostaglandins; reactions catalysed include
            hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-,S-
            and O-dealkylations, desulfation, deamination, and reduction of
            azo, nitro, and N-oxide groups. Together with EC 1.6.2.4 forms a
            system in which two reducing equivalents are supplied by NADPH.
            Formerly EC 1.14.1.1, 1.14.99.8 and 1.99.1.1. Some of the
            reactions attributed to EC 1.14.15.3 belong here.
            (EC 1.6.2.4 NADPH-ferrihemoprotein reductase)
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00380  Tryptophan metabolism
DISEASE     MIM: 107910  Cytochrome P450, subfamily XIX (aromatization of
                         androgens); ?Gynecomastia, familial, due to increased
                         aromatase activity 3.4.14.10:
            MIM: 124010  Cytochrome P450, subfamily IIIA (nifedipine oxidase)
                         polypeptide 4
            MIM: 124020  Cytochrome P450, subfamily IIC; mephenytoin
                         4'-hydroxylase; Mephenytoin poor metabolizer (3)
            MIM: 124040  Cytochrome P450, subfamily IIE (ethanol-inducible)
            MIM: 124075  Cytochrome P450, subfamily IVB, member 1
            MIM: 190470  Tripeptidyl peptidase II
            MIM: 601637  Cytochrome P450, 51 (lanosterol 14-alpha-demethylase)
MOTIF       PS: PS00086  F-[SGNH]-x-[GD]-x-[RHPT]-x-C-[LIVMFAP]-[GAD]
GENES       SCE: YDR402C(DIT2) YHR007C(ERG11)
            HSA: AHHR(AHH) CYP1A1(CYP1) CYP1A2(Hs.74042)
STRUCTURES  PDB: 1FAG  1FAH  2BMH  2HPD  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.14.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.14.1
            SCOP (Structural Classificaion of Proteins): 1.14.14.1
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