ENTRY       EC 1.14.13.8
NAME        Dimethylaniline monooxygenase (N-oxide-forming)
            Dimethylaniline oxidase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     N,N-Dimethylaniline,NADPH:oxygen oxidoreductase(N-oxide-forming)
REACTION    N,N-Dimethylaniline + NADPH + O2 = N,N-Dimethylaniline N-oxide +
            NADP+ + H2O
SUBSTRATE   N,N-Dimethylaniline
            NADPH
            O2
            Dialkylarylamine
PRODUCT     N,N-Dimethylaniline N-oxide
            NADP+
            H2O
COFACTOR    Flavin
COMMENT     A flavoprotein. Acts on various dialkylarylamines.
DISEASE     MIM: 136130  Flavin-containing monooxygenase 1 (fetal liver)
            MIM: 136131  Flavin-containing monooxygenase 2 (adult liver)
            MIM: 136132  Flavin-containing monooxygenase-3; [Fish-odor
                         syndrome], 602079 (3)
GENES       HSA: FMO1(Hs.1424) FMO3(FMOII) FMO4(FMO2)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.8
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.8
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