ENTRY       EC 1.14.13.54
NAME        Steroid monooxygenase
            Steroid-ketone monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    Progesterone + NADPH + O2 = Testosterone acetate + NADP+ + H2O
SUBSTRATE   Progesterone
            NADPH
            O2
            Androstenedione
            17-alpha-Hydroxyprogesterone
PRODUCT     Testosterone acetate
            NADP+
            H2O
            Testolactone
            Androstenedione
            Acetic acid
COMMENT     Also acts on Androst-4-ene-3,17-dione (Androstenedione) to produce
            3-Oxo-13,17-decoandrost-4-eno-17,13-alpha-lactone (Testolactone).
            Also acts on Pregn-4-ene-3,20-dione-17-ol (17-alpha-
            Hydroxyprogesterone) to produce Androst-4-ene-3,17-dione
            (Androstenedione) + Acetic acid.
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.54
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.54
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