ENTRY       EC 1.14.13.53
NAME        Isoflavone 2'-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)
REACTION    Formononetin + NADPH + O2 = 2'-Hydroxyformononetin + NADP+ + H2O
SUBSTRATE   Formononetin
            NADPH
            O2
PRODUCT     2'-Hydroxyformononetin
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450). Acts on isoflavones with a
            4'-methoxy group. Involved in the biosynthesis of the
            pterocarpin phytoalexins medicarpin and maachiain.
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.53
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.53
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