ENTRY       EC 1.14.13.34
NAME        Leukotriene-E4 20-monooxygenase
            Leukotriene-E4 omega-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-
            $tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
REACTION    (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,
            $14-tetraenoate + NADPH + O2 = 20-Hydroxy-leukotriene E4 + NADP+
            + H2O
SUBSTRATE   (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,
            $14-tetraenoate
            NADPH
            O2
PRODUCT     20-Hydroxy-leukotriene E4
            NADP+
            H2O
COMMENT     Also acts on N-acetyl-leukotriene E4, more slowly. Not identical
            with EC 1.14.13.30.
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.34
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.34
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