ENTRY       EC 1.14.13.30
NAME        Leukotriene-B4 20-monooxygenase
            Leukotriene-B4 20-hydroxylase
            Leukotriene-B4 omega-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyicosa-6,8,10,14-
            $tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
REACTION    (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-
            $tetraenoate + NADPH + O2 =
            (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-
            $tetraenoate + NADP+ + H2O
SUBSTRATE   (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-
            $tetraenoate
            NADPH
            O2
PRODUCT     (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-
            $tetraenoate
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450).  Not identical with 1.14.13.34.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
MOTIF       PS: PS00086  F-[SGNH]-x-[GD]-x-[RHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.30
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.30
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