ENTRY       EC 1.14.13.25
NAME        Methane monooxygenase
            Methane hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)
REACTION    Methane + NADH + O2 = Methanol + NAD+ + H2O;
            Methane + NADPH + O2 = Methanol + NADP+ + H2O;
            Alkene + NADH + O2 = Epoxide + NAD+ + H2O
SUBSTRATE   Methane
            Alkene
            Aromatic alkane
            Alkane
            NH3
            CO
            NADPH
            NADH
            O2
PRODUCT     Methanol
            Epoxide
            CO2
            NADP+
            NAD+
            H2O
            Hydroxylamine
COFACTOR    Iron
COMMENT     Broad specificity; many alkanes can be hydroxylated, and alkenes
            are converted into the corresponding epoxides; CO is oxidized to
            CO2, ammonia is oxidized to hydroxylamine, and some aromatic
            compounds and cyclic alkanes can also be hydroxylated, more
            slowly. Nonheme diiron enzyme instead of Fe-porphyrin cofactor.
            Consists of three separate protein components; hydroxylase, 
            reductase, and component B.  The hydroxylase component has diiron
            reaction center.  Proposed intermediate Q has a diamond core 
            structure containing two iron (IV) atoms and two oxygen atoms.
PATHWAY     PATH: MAP00680  Methane metabolism
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{cpdhtmEKRHFYW}-C
STRUCTURES  PDB: 1MHY  1MHZ  1MMO  1MTY  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.25
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.25
            SCOP (Structural Classificaion of Proteins): 1.14.13.25
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