ENTRY       EC 1.14.13.18
NAME        4-Hydroxyphenylacetate 1-monooxygenase
            4-Hydroxyphenylacetate 1-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     4-Hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase
            $ (1-hydroxylating)
REACTION    4-Hydroxyphenylacetate + NADH or NADPH + O2 = Homogentisate +
            NAD+ or NADP+ + H2O
SUBSTRATE   4-Hydroxyphenylacetate
            NADH
            NADPH
            O2
            4-Hydroxyhydratropate
            4-Hydroxypheoxyacetate
PRODUCT     Homogentisate
            NAD+
            NADP+
            H2O
            2-Methylhomogentisate
            Hydroquinone
            Glycolate
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Also acts on 4-hydroxyhydratropate (forming
            2-methylhomogentisate) and on 4-hydroxyphenoxyacetate (forming
            hydroquinone and glycolate).
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.18
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.18
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