ENTRY       EC 1.14.13.17
NAME        Cholesterol 7alpha-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
REACTION    Cholesterol + NADPH + O2 = 7alpha-Hydroxycholesterol + NADP+ + H2O
SUBSTRATE   Cholesterol
            NADPH
            O2
PRODUCT     7alpha-Hydroxycholesterol
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450).
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DISEASE     MIM: 118455  Cytochrome P450, subfamily VII (cholesterol
                         7-alpha-monooxygenase)
MOTIF       PS: PS00086  F-[SGNH]-x-[GD]-x-[RHPT]-x-C-[LIVMFAP]-[GAD]
GENES       HSA: CYP7A1(CYP7)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.17
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.17
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