ENTRY       EC 1.14.13.11
NAME        trans-Cinnamate 4-monooxygenase
            Cinnamic acid 4-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
SYSNAME     trans-Cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)
REACTION    trans-Cinnamate + NADPH + O2 = trans-4-Hydroxycinnamate + NADP+ + 
            H2O
SUBSTRATE   trans-Cinnamate
            NADPH
            O2
            NADH
PRODUCT     trans-4-Hydroxycinnamate
            NADP+
            H2O
            NAD+
COFACTOR    Heme
COMMENT     NADH also acts, more slowly. Involves a heme-thiolate protein
            (P-450).
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
MOTIF       PS: PS00086  F-[SGNH]-x-[GD]-x-[RHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.13.11
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.11
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