ENTRY       EC 1.14.12.7
NAME        Phthalate 4,5-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     Phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)
REACTION    Phthalate + NADH + O2 =
            cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate +
            NAD+ + H2O
SUBSTRATE   Phthalate
            NADH
            O2
PRODUCT     cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate
            NAD+
            H2O
COFACTOR    Iron
COMMENT     A system, containing a reductase which is an iron-sulfur
            flavoprotein (FMN), an iron-sulfur oxygenase, and no independent
            ferredoxin. Requires Fe2+.
DBLINKS     University of Geneva ENZYME DATA BANK: 1.14.12.7
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.7
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