ENTRY       EC 1.13.99.3
NAME        Tryptophan 2'-dioxygenase
            Indole-3-alkane alpha-hydroxylase
            Tryptophan side-chain alpha,beta-oxidase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            Miscellaneous
SYSNAME     L-Tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)
REACTION    L-Tryptophan + O2 = 3-Indoleglycolaldehyde + CO2 + NH3
SUBSTRATE   L-Tryptophan
            O2
            5-Hydroxy-L-tryptophan
PRODUCT     3-Indoleglycolaldehyde
            CO2
            NH3
COFACTOR    Heme
COMMENT     A hemoprotein.  Acts on a number of indolyl-3-alkane derivatives,
            oxidizing the 3-side-chain in the 2'-position.  Best substrates
            were L-tryptophan and 5-hydroxy-L-tryptophan.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.13.99.3
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