ENTRY       EC 1.13.12.7
NAME        Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)
            Firefly luciferase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     Photinus-luciferin:oxygen 4-oxidoreductase(decarboxylating,
            ATP-hydrolysing)
REACTION    Photinus luciferin + O2 + ATP = Oxidized Photinus luciferin +
            CO2 + H2O + AMP + Pyrophosphate + hv
SUBSTRATE   Photinus luciferin
            (S)-4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-
            $thiazolecarboxylic acid
            O2
            ATP
PRODUCT     Oxidized Photinus luciferin
            CO2
            H2O
            AMP
            Pyrophosphate
            hv
COMMENT     Photinus luciferin is (S)-4,5-dihydro-2-(6-hydroxy-2-benzothia-
            zolyl)-4-thiazolecarboxylic acid. The first step in the reaction
            is the formation of an acid anhydride between the carboxylic
            group and AMP, with the release of pyrophosphate. The enzyme
            may be assayed by measurement of light emission.
MOTIF       PS: PS00342  [SAGCN]-[RKH]-[LIVMAF]>
            PS: PS00455  [LIVMFY]-x(2)-[STG](2)-G-[ST]-[STEI]-[SG]-x-[PASLIVM]-K
STRUCTURES  PDB: 1LCI  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.13.12.7
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.7
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