ENTRY       EC 1.11.1.9
NAME        Glutathione peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Glutathione:hydrogen-peroxide oxidoreductase
REACTION    2 Glutathione + H2O2 = Oxidized glutathione + 2 H2O
SUBSTRATE   Glutathione
            H2O2
            Steroid hydroperoxide
            Lipid hydroperoxide
PRODUCT     Oxidized glutathione
            H2O
COFACTOR    Selenium
COMMENT     A protein containing a selenocysteine residue. Steroid and lipid
            hydroperoxides, but not the product of reaction of EC 1.13.11.12
            on phospholipids, can act as acceptor, but more slowly than H2O2.
            (cf. EC 1.11.1.12)
            #STRUCTURE:
            Residue 45 is selenocysteine in rat and bovine enzymes. This
            residue is coded by a stop codon, TGA (Chambers et al. EMBO J.,
            5, 1221-1227, 1986) and is derived from serine pretranscriptional.
            (Sunde and Everson, J. Biol. Chem., 262, 933-937, 1987).
PATHWAY     PATH: MAP00480  Glutathione metabolism
DISEASE     MIM: 138319  Glutathione peroxidase 2 (gastrointestinal)
            MIM: 138320  Glutathione peroxidase-1; Hemolytic anemia due to
                         glutathione peroxidase deficiency (1)
            MIM: 138321  Glutathione peroxidase 3 (plasma)
MOTIF       PS: PS00460  [GN]-[RKHNFYC]-x-[LIVMFC]-[LIVMF](2)-x-N-V-x-[STC]-x-C-
                         [GA]-x-T
            PS: PS00763  [LIV]-[AG]-F-P-[CS]-[NG]-Q-F
GENES       SYN: slr1171 slr1992
            SCE: YBR244W(YBR1632) YIR037W(HYR1) YKL026C
            HSA: GPX1(Hs.76686) GPX5 GPX6
STRUCTURES  PDB: 1GP1  
DBLINKS     University of Geneva ENZYME DATA BANK: 1.11.1.9
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.9
            SCOP (Structural Classificaion of Proteins): 1.11.1.9
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