ENTRY       EC 1.11.1.8
NAME        Iodide peroxidase
            Iodotyrosine deiodase
            Iodinase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Iodide:hydrogen-peroxide oxidoreductase
REACTION    Iodide + H2O2 = Iodine + 2 H2O
SUBSTRATE   Iodide
            H2O2
PRODUCT     Iodine
            H2O
COFACTOR    Heme
COMMENT     A hemoprotein.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DISEASE     MIM: 274500  Thyroid peroxidase; Thyroid iodine peroxidase
                         deficiency (1); Goiter, congenital (3); Hypothyroidism,
                         congenital (3)
MOTIF       PS: PS00435  [DET]-[LIVMTA]-x(2)-[LIVM]-[LIVMSTAG]-[SAG]-[LIVMSTAG]-
                         H-[STA]-[LIVMFY]
            PS: PS00436  [SGATV]-x(3)-[LIVMA]-R-[LIVMA]-x-[FW]-H-x-[SAC]
DBLINKS     University of Geneva ENZYME DATA BANK: 1.11.1.8
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.8
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