ENTRY       EC 1.11.1.12
NAME        Phospholipid-hydroperoxide glutathione peroxidase
            Peroxidation-inhibiting protein
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Glutathione:lipid-hydroperoxide oxidoreductase
REACTION    2 Glutathione + a Lipid hydroperoxide = Oxidized glutathione +
            Lipid + 2 H2O
SUBSTRATE   Glutathione
            Lipid hydroperoxide
PRODUCT     Oxidized glutathione
            Lipid
            H2O
COMMENT     A protein containing a selenocysteine residue.  The products of
            action of EC 1.13.11.12 on phospholipids can act as acceptor;
            H2O2 can also act, but much more slowly (cf. EC 1.11.19).
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 1.11.1.12
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.12
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