ENTRY       EC 1.10.3.4
NAME        o-Aminophenol oxidase
            Isophenoxazine synthase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With oxygen as acceptor
SYSNAME     2-Aminophenol:oxygen oxidoreductase
REACTION    2 2-Aminophenol + 3 O2 = 2 Isophenoxazine + 6 H2O
SUBSTRATE   2-Aminophenol
            O2
PRODUCT     Isophenoxazine
            H2O
COFACTOR    FAD
            Manganese
COMMENT     A flavoprotein, requiring Mn2+.  Isophenoxazine may be formed by
            a secondary condensation from the initial oxidation product.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 1.10.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.10.3.4
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