ENTRY       EC 1.1.4.2
NAME        Vitamin-K-epoxide reductase (warfarin-insensitive)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a disulfide as acceptor
SYSNAME     3-Hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:
            $oxidized-dithiothreitol oxidoreductase
REACTION    2-Hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone +
            Oxidized dithiothreitol + H2O =
            2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone +
            1,4-Dithiothreitol
SUBSTRATE   2-Hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone
            Oxidized dithiothreitol
            H2O
            3-Hydroxy-vitamin K
            2-Hydroxy-vitamin K
PRODUCT     2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone
            1,4-Dithiothreitol
            Vitamin K 2,3-epoxide
COMMENT     In the reverse reaction, vitamin K 2,3-epoxide is reduced to
            3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol,
            which is oxidized to a disulfide.  Not inhibited by warfarin
            (cf. 1.1.4.1).
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.4.2
            WIT (What Is There) Metabolic Reconstruction: 1.1.4.2
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