ENTRY       EC 1.1.4.1
NAME        Vitamin-K-epoxide reductase (warfarin-sensitive)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a disulfide as acceptor
SYSNAME     2-Methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol
            $ oxidoreductase
REACTION    2-Methyl-3-phytyl-1,4-naphthoquinone + Oxidized dithiothreitol +
            H2O =
            2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone +
            1,4-Dithiothreitol
SUBSTRATE   2-Methyl-3-phytyl-1,4-naphthoquinone
            Oxidized dithiothreitol
            H2O
            Vitamin K
            Vitamin K hydroquinone
PRODUCT     2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone
            1,4-Dithiothreitol
            Vitamin K 2,3-epoxide
INHIBITOR   Warfarin
COMMENT     In the reverse reaction, vitamin K 2,3-epoxide is reduced to
            vitamin K and possibly to vitamin K hydroquinone by
            1,4-dithiothreitol, which is oxidized to a disulfide; some other
            dithiols and 4-butanethiol can also act.  Inhibited strongly by
            warfarin (cf. EC 1.1.4.2).
PATHWAY     PATH: MAP00100  Sterol biosynthesis
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.4.1
            WIT (What Is There) Metabolic Reconstruction: 1.1.4.1
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