ENTRY       EC 1.1.3.34
NAME        Berbamunine synthase
            (S)-N-Methylcoclaurine oxidase (C-O phenol-coupling)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
REACTION    (S)-N-Methylcoclaurine + (R)-N-Methylcoclaurine + NADPH + O2 =
            Berbamunine + NADP+ + 2 H2O
SUBSTRATE   (S)-N-Methylcoclaurine
            (R)-N-Methylcoclaurine
            NADPH
            O2
PRODUCT     Berbamunine
            NADP+
            H2O
COMMENT     Forms the bisbenzylquinone alkaloid Berbamunine by phenol oxidation
            of N-Methylcoclaurine without the incorporation of oxygen into the
            product.
            Reaction of 2 molecules of (R)-N-Methylcoclaurine gives the dimer
            Guattagaumerine.
MOTIF       PS: PS00086  F-[SGNH]-x-[GD]-x-[RHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.3.34
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.34
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