ENTRY       EC 1.1.3.26
NAME        Columbamine oxidase
            Berberine synthase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Columbamine:oxygen oxidoreductase (cyclizing)
REACTION    2 Columbamine + O2 = 2 Berberine + 2 H2O
SUBSTRATE   Columbamine
            O2
PRODUCT     Berberine
            H2O
COFACTOR    Iron
COMMENT     Oxidation of the O-methoxyphenol structure forms the
            methylenedioxy group of berberine.  An iron protein.
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.3.26
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.26
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