ENTRY       EC 1.1.1.205
NAME        IMP dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     IMP:NAD+ oxidoreductase
REACTION    Inosine 5'-phosphate + NAD+ + H2O = Xanthosine 5'-phosphate + NADH
SUBSTRATE   Inosine 5'-phosphate
            NAD+
            H2O
PRODUCT     Xanthosine 5'-phosphate
            NADH
COMMENT     The enzyme acts on the hydroxyl group of the hydrated derivative
            of the substrate. Formerly EC 1.2.1.14.
PATHWAY     PATH: MAP00230  Purine metabolism
DISEASE     MIM: 146690  IMP (inosine monophosphate) dehydrogenase 1
            MIM: 146691  IMP (inosine 5'-phosphate) dehydrogenase-2
MOTIF       PS: PS00487  [LIVM]-[RK]-[LIVM]-G-[LIVM]-G-x-G-S-[LIVM]-C-x-T
GENES       MJA: MJ1616(guaB)
            MTH: MTH142
            ECO: b2508(guaB)
            HIN: HI0221(guaB)
            HPY: HP0829(guaB)
            BSU: guaB(guaA) yhcV
            SYN: slr0172(guaB) slr1722(guaB)
            SCE: YAR073W(FUN63) YHR216W(PUR5) YLR432W(L9753.4)
                 YML056C(YM9958.06C)
            HSA: IMPDH1(Hs.850) IMPDH2(Hs.75432)
DBLINKS     University of Geneva ENZYME DATA BANK: 1.1.1.205
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.205
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