Two-Component System

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Group 1. OmpR family

Subgroup 1.1

Organism	Signal	Sensor kinase	Response regulator	Transcribed genes	Comment
eco [ P \| G \| T ]	Phosphate	b0400(phoR)	b0399(phoB)	b0383(phoA)	Alkaline phosphatase
hin [ P \| G \| T ]		HI1378	HI1379
rpr [ P \| G \| T ]		RP465
bsu [ P \| G \| T ]	Phosphate	phoR	phoP
tma [ P \| G \| T ]		TM1654	TM1655
tma [ P \| G \| T ]		TM0853
mtu [ P \| G \| T ]		Rv0490	Rv0491
mtu [ P \| G \| T ]		Rv3245c	Rv3246c
syn [ P \| G \| T ]		sll0790	sll0789
syn [ P \| G \| T ]		sll0798	sll0797
syn [ P \| G \| T ]			slr0081
bsu [ P \| G \| T ]	Respiration	resE	resD
bsu [ P \| G \| T ]		yycG	yycF
bsu [ P \| G \| T ]		yvrG	yvrH
aae [ P \| G \| T ]		aq_316	aq_319
tma [ P \| G \| T ]		TM1258	TM1259
eco [ P \| G \| T ]	Osmotic pressure	b3404(envZ)	b3405(ompR)	b2215(ompC) b0929(ompF)	Outer membrane proteins
sty [ P \| G \| T ]	Osmotic pressure	envZ	ompR		Outer membrane proteins
rpr [ P \| G \| T ]		RP426	RP427
bsu [ P \| G \| T ]		yclK	yclJ
bsu [ P \| G \| T ]		ykoH	ykoG
mtu [ P \| G \| T ]		Rv0758	Rv0757
mtu [ P \| G \| T ]		Rv1032c	Rv1033c
mtu [ P \| G \| T ]		Rv3764c	Rv3765c
mtu [ P \| G \| T ]		Rv0982	Rv0981
eco [ P \| G \| T ]	Stress	b1609(rstB)	b1608(rstA)
eco [ P \| G \| T ]		b3911(cpxA)	b3912(cpxR)		Cell envelope protein control
hin [ P \| G \| T ]			HI0837
eco [ P \| G \| T ]		b4399(creC)	b4398(creB)		Catabolite repression
eco [ P \| G \| T ]		b2078(baeS)	b2079(baeR)
syn [ P \| G \| T ]		slr0533
bsu [ P \| G \| T ]		yvqB	yvqA
eco [ P \| G \| T ]		b4112(basS)	b4113(basR)		Virulence
sty [ P \| G \| T ]		pmrB(basS)	pmrA(basR)		Virulence
eco [ P \| G \| T ]		b0570(ybcZ)	b0571(ylcA)
eco [ P \| G \| T ]		b1968(yedV)	b1969(yedW)
eco [ P \| G \| T ]		b3026(ygiY)	b3025(ygiX)
tma [ P \| G \| T ]		TM0400	TM0399
hin [ P \| G \| T ]		HI1707	HI1708
rpr [ P \| G \| T ]			RP071
sty [ P \| G \| T ]			tctD
eco [ P \| G \| T ]	Stress	b1129(phoQ)	b1130(phoP)	b0980(appA)
sty [ P \| G \| T ]		phoQ	phoP

Subgroup 1.2

Organism	Signal	Sensor kinase	Response regulator	Transcribed genes	Comment
eco [ P \| G \| T ]	Turgor pressure	b0695(kdpD)	b0694(kdpE)	b0698(kdpA) b0697(kdpB) b0696(kdpC)	Potassium transport
mtu [ P \| G \| T ]		Rv1028c	Rv1027c	Rv1029 Rv1030 Rv1031
syn [ P \| G \| T ]		slr1731	sll0396	slr1728 slr1729 slr1730
eco [ P \| G \| T ]	Trimethylamine N-oxide	b0993(torS)	b0995(torR)	b0996(torC) b0997(torA) b0998(torD)	[Hybrid]
eco [ P \| G \| T ]		b3210(arcB)	b4401(arcA)		Aerobic respiration [Hybrid]
hin [ P \| G \| T ]		HI0220	HI0884
bsu [ P \| G \| T ]		ytsB	ytsA
bsu [ P \| G \| T ]		yvcQ	yvcP
bsu [ P \| G \| T ]		yxdK	yxdJ
hpy [ P \| G \| T ]		HP0164	HP0166
hpj [ P \| G \| T ]		jhp0151	jhp0152
bsu [ P \| G \| T ]		ybdK	ybdJ
bsu [ P \| G \| T ]		ycbM	ycbL
bsu [ P \| G \| T ]		yrkQ	yrkP
mtu [ P \| G \| T ]		Rv0902c	Rv0903c
mtu [ P \| G \| T ]		Rv0600c	Rv0602c
mtu [ P \| G \| T ]		Rv0601c	Rv0602c
tma [ P \| G \| T ]		TM0127	TM0126

Group 2. NarL family

Subgroup 2.1

Organism	Signal	Sensor kinase	Response regulator	Transcribed genes	Comment
eco [ P \| G \| T ]	Nitrate	b1222(narX)	b1221(narL)	b1224(narG) b1225(narH) b1226(narJ) b1227(narI)
eco [ P \| G \| T ]	Nitrate	b2469(narQ)	b2193(narP)
hin [ P \| G \| T ]		HI0267	HI0726
syn [ P \| G \| T ]		slr0311	slr0312
mtu [ P \| G \| T ]		Rv3132c	Rv3133c
mtu [ P \| G \| T ]		Rv0845	Rv0844c
eco [ P \| G \| T ]	Hexose phosphates	b3668(uhpB)	b3669(uhpA)	b3666(uhpT)
sty [ P \| G \| T ]	Hexose phosphates	uhpB	uhpA	uhpT
bsu [ P \| G \| T ]	Exogeneous DNA	comP	comA		Competence
bsu [ P \| G \| T ]	Exogeneous DNA	degS	degU		Degradative enzyme and competence regulation
bsu [ P \| G \| T ]		ydfH	ydfI
bsu [ P \| G \| T ]		yvqE	yvqC
bsu [ P \| G \| T ]		yhcY	yhcZ
bsu [ P \| G \| T ]		yfiJ	yfiK
bsu [ P \| G \| T ]		yocF	yocG
bsu [ P \| G \| T ]		yvfT	yvfU
bsu [ P \| G \| T ]		yxjM	yxjL

Subgroup 2.2

Organism	Sensor kinase	Response regulator	Comment
eco [ P \| G \| T ]	b2216(yojN)	b2217(rcsB)
eco [ P \| G \| T ]	b2218(rcsC)		Capsule synthesis [Hybrid]
eco [ P \| G \| T ]	b2370(evgS)	b2369(evgA)	[Hybrid]
syn [ P \| G \| T ]	sll1590	sll1592
syn [ P \| G \| T ]	slr1805	sll1708

Subgroup 2.3

Organism	Response regulator	Comment
eco [ P \| G \| T ]	b0535(fimZ)	Fimbrial synthesis
sty [ P \| G \| T ]	fimZ	Fimbrial synthesis
eco [ P \| G \| T ]	b1914(uvrY)

Group 3. NtrC family

Subgroup 3.1

Organism	Sensor kinase	Response regulator	Transcribed genes	Comment
eco [ P \| G \| T ]	b3869(ntrB)	b3868(ntrC)	b3870(glnA)	Nitrogen regulation
sty [ P \| G \| T ]	glnL(ntrB)	glnG(ntrC)	glnA	Nitrogen regulation
rpr [ P \| G \| T ]		RP562
sty [ P \| G \| T ]	pgtB	pgtA	pgtC
aae [ P \| G \| T ]	aq_1115	aq_1117	aq_111
aae [ P \| G \| T ]		aq_1792
aae [ P \| G \| T ]	aq_231	aq_230
aae [ P \| G \| T ]		aq_164
eco [ P \| G \| T ]	b4003(hydH)	b4004(hydG)		Labile hydrogenase activity
sty [ P \| G \| T ]	hydH	hydG		Labile hydrogenase activity
eco [ P \| G \| T ]	b2219(atoS)	b2220(atoC)		Acetoacetate metabolism
bbu [ P \| G \| T ]	BB0764	BB0763
tpa [ P \| G \| T ]		TP0519
hpy [ P \| G \| T ]	HP0244	HP0703
hpj [ P \| G \| T ]	jhp0229	jhp0643
ctr [ P \| G \| T ]	CT467	CT468
cpn [ P \| G \| T ]	CPn0584	CPn0586

Subgroup 3.2

Organism	Signal	Sensor kinase	Response regulator	Transcribed genes	Comment
eco [ P \| G \| T ]		b2556(yfhK)	b2554(yfhA)

Group 4. Spo0A family

Organism	Sensor kinase	Response regulator	Comment
bsu [ P \| G \| T ]	kinA	spo0F	Sporulation
bsu [ P \| G \| T ]	kinB	spo0F
bsu [ P \| G \| T ]	kinC	spo0A
bsu [ P \| G \| T ]	spo0B	spo0A

Group 5. CheY family

Organism	Sensor kinase	Response regulator	Comment
eco [ P \| G \| T ]	b1888(cheA)	b1882(cheY)	Chemotaxis; flagellar switch
eco [ P \| G \| T ]	b1888(cheA)	b1883(cheB)	Chemotaxis; methylesterase
bsu [ P \| G \| T ]	cheA	cheB
bsu [ P \| G \| T ]	cheA	cheY
bsu [ P \| G \| T ]	cheV		[Hybrid]
hpy [ P \| G \| T ]	HP0392	HP0393	[Hybrid]
hpy [ P \| G \| T ]		HP1067
hpj [ P \| G \| T ]	jhp0989	jhp0988
hpj [ P \| G \| T ]		jhp0358
syn [ P \| G \| T ]	sll0043	sll0039
syn [ P \| G \| T ]		sll0038
syn [ P \| G \| T ]	sll1296	sll1292
syn [ P \| G \| T ]		sll1291
tma [ P \| G \| T ]	TM0702(cheA)	TM0700(cheY)
tma [ P \| G \| T ]		TM0408
afu [ P \| G \| T ]	AF1040	AF1041
afu [ P \| G \| T ]	AF1040	AF1042
pab [ P \| G \| T ]	PAB1332	PAB1330
pab [ P \| G \| T ]	PAB1332	PAB1331
bbu [ P \| G \| T ]	BB0567	BB0568
bbu [ P \| G \| T ]		BB0570
bbu [ P \| G \| T ]	BB0669(cheA)	BB0672
tpa [ P \| G \| T ]	TP0363(cheA)	TP0366
tpa [ P \| G \| T ]		TP0631
tpa [ P \| G \| T ]	TP0364
tpa [ P \| G \| T ]	TP0439
pho [ P \| G \| T ]	PH0486	PH0483
pho [ P \| G \| T ]		PH0482
pho [ P \| G \| T ]	PH0478

Group 6. CitB family

Organism	Sensor kinase	Response regulator
eco [ P \| G \| T ]	b0619	b0620
bsu [ P \| G \| T ]	ydbF	ydbG
bsu [ P \| G \| T ]	citS	citT
eco [ P \| G \| T ]	b4125(yjdH)	b4124(yjdG)
bsu [ P \| G \| T ]	yufL	yufM

Group 7. LytT family

Organism	Sensor kinase	Response regulator	Comment
eco [ P \| G \| T ]	b2126(yehU)	b2125(yehT)
eco [ P \| G \| T ]	b2380	b2381
bsu [ P \| G \| T ]	lytS	lytT	Rate of autolysis
bsu [ P \| G \| T ]	yccG	yccH

Group 8. Other families

Organism	Sensor kinase	Response regulator	Comment
eco [ P \| G \| T ]		b1235(hnr)
eco [ P \| G \| T ]	b2786(barA)		(Supressor of envZ) [Hybrid]
bsu [ P \| G \| T ]	ywpD		[Hybrid]
bsu [ P \| G \| T ]	ycbA	ycbB
bsu [ P \| G \| T ]	yesM	yesN
hpy [ P \| G \| T ]	HP1364	HP1365
hpj [ P \| G \| T ]	jhp1282	jhp1443
hpy [ P \| G \| T ]		HP0616
hpj [ P \| G \| T ]		jhp0559
hpy [ P \| G \| T ]		HP0019
hpj [ P \| G \| T ]		jhp0017
hpy [ P \| G \| T ]		HP1043
hpj [ P \| G \| T ]		jhp0381
hpy [ P \| G \| T ]		HP1021
hpj [ P \| G \| T ]		jhp0403
rpr [ P \| G \| T ]	RP229	RP237
rpr [ P \| G \| T ]	RP614
mth [ P \| G \| T ]	MTH444	MTH445
mth [ P \| G \| T ]		MTH446
mth [ P \| G \| T ]		MTH447
mth [ P \| G \| T ]	MTH459	MTH457
mth [ P \| G \| T ]		MTH548
mth [ P \| G \| T ]	MTH901	MTH902
bbu [ P \| G \| T ]	BB0420	BB0419	[Hybrid]
tma [ P \| G \| T ]	TM1359	TM1360
tma [ P \| G \| T ]		TM0143
tma [ P \| G \| T ]		TM0186
tma [ P \| G \| T ]		TM0468
tma [ P \| G \| T ]		TM0842
afu [ P \| G \| T ]	AF0450	AF0449
afu [ P \| G \| T ]	AF1472	AF1473	[Hybrid]
afu [ P \| G \| T ]	AF2420	AF2419
syn [ P \| G \| T ]	sll1228	sll1229
syn [ P \| G \| T ]	sll1672	sll1673
syn [ P \| G \| T ]	slr1759	slr1760
syn [ P \| G \| T ]	slr2098
syn [ P \| G \| T ]	slr2099	slr2100
syn [ P \| G \| T ]	slr2104
syn [ P \| G \| T ]	sll1871	slr1982
syn [ P \| G \| T ]	sll1871	slr1983
sce [ P \| G \| T ]	YIL147C		High osmolarity
sce [ P \| G \| T ]	YDL235C(ypd1)	YLR006C(ssk1)	High osmolarity
syn [ P \| G \| T ]	slr0473	slr0474	similar to phytochrome

Last updated: Aug 8, 1999
Compiled by KEGG with the classification by Hidemasa Bono