Original URL: http://www.genome.ad.jp/kegg/kegg1.html

	Introduction to KEGG

Documents

• From sequence to function: an introduction to the KEGG project
• A Quick Guide to KEGG (May 1998) [pdf]
• KEGG - From Genes to Biochemical Pathways (July 1998) [pdf]
• Biological Knowledge Base KEGG for Post-Genome Analysis - In Japanese (June 1997) [pdf]
• Grand challenges in bioinformatics - Editorial in Bioinformatics

Slide Show

• Is genome a blueprint of life? - Philosophical background of KEGG
• Toward reconstruction of a biological organism - Conceptual framework for functional genomics

Tutorial

• Course 1: From pathway to genes and molecules
• Course 2: From genes and molecules to pathway

On-line Manuals

• How to use pathway maps
• How to perform pathway search
• How to use hierarchical texts
• How to use java applets for genome maps
• How to use java applet for genome map comparison

Additional Documents

• Release notes
• How to download the KEGG system
• URLs for making DBGET/LinkDB/KEGG queries

1. Kanehisa, M.; Toward pathway engineering: a new database of genetic and molecular pathways. Science & Technology Japan, No. 59, pp. 34-38 (1996). [pdf] [ps]
2. Kanehisa, M. and Goto, S.; A systematic analysis of gene functions by the metabolic pathway database. In "Theoretical and Computational Methods in Genome Research" (Suhai, S., ed.), pp. 41-55, Plenum Press (1997). [ISBN:0-306-45503-X]
3. Goto, S., Bono, H., Ogata, H., Fujibuchi, W., Nishioka, T., Sato, K., and Kanehisa, M.; Organizing and computing metabolic pathway data in terms of binary relations. Pacific Symp. Biocomputing 2, 175-186 (1996). [9390290] [pdf] [ps]
4. Kanehisa, M.; A database for post-genome analysis. Trends Genet. 13, 375-376 (1997). [9287494]
5. Kanehisa, M.; KEGG - From genes to biochemical pathways. In "Molecular Biology Databases" (Letovsky, S., ed.), in press, Kluwer Academic Press (1998).
6. Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., and Kanehisa, M.; KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 27, 29-34 (1999). [9847135]

1. Ogata, H., Bono, H., Fujibuchi, W., Goto, S., and Kanehisa, M.; Analysis of binary relations and hierarchies of enzymes in the metabolic pathways. Genome Informatics 7, 128-136 (1996). [GIW96014] [pdf] [ps]
2. Bono, H., Ogata, H., Goto, S., and Kanehisa, M.; Reconstruction of amino acid biosynthesis pathways from the complete genome sequence. Genome Res. 8, 203-210 (1998). [9521924]
3. Ogata, H., Goto, S., Fujibuchi, W., and Kanehisa, M.; Computation with the KEGG pathway database. BioSystems 47, 119-128 (1998). [9799792]
4. Tomii, K. and Kanehisa, M.; A comparative analysis of ABC transporters in the complete microbial genomes. Genome Res. 8, 1048-1059 (1998). [9799792]
5. Bono, H., Goto, S., Fujibuchi, W., Ogata, H., and Kanehisa, M.; Systematic prediction of orthologous units of genes in the complete genomes. Genome Informatics 9, 32-40 (1998). [pdf]

1. Akiyama, Y., Goto, S., Uchiyama, I., and Kanehisa, M.; WebDBGET: an integrated database retrieval system which provides hyper-links among related entries. MIMBD'95: Second Meeting on the Interconnection of Molecular Biology Databases (1995). [pdf] [ps]
2. Goto, S., Akiyama, Y., and Kanehisa, M.; LinkDB: a database of cross links between molecular biology databases. MIMBD'95: Second Meeting on the Interconnection of Molecular Biology Databases (1995). [pdf] [ps]
3. Kanehisa, M.; Linking databases and organisms: GenomeNet resources in Japan. Trends Biochem Sci. 22, 442-444 (1997). [9397687]
4. Fujibuchi, W., Goto, S., Migimatsu, H., Uchiyama, I., Ogiwara, A., Akiyama, Y., and Kanehisa, M.; DBGET/LinkDB: an Integrated Database Retrieval System. Pacific Symp. Biocomputing 3, 683-694 (1997). [9697222] [pdf] [ps]
5. Fujibuchi, W., Sato, K., Ogata, H., Goto, S., and Kanehisa, M.; KEGG and DBGET/LinkDB: Integration of biological relationships in divergenet molecular biology data. In "Knowledge Sharing Across Biological and Medical Knowledge Based Systems", Technical Report WS-98-04, pp. 35-40, AAAI Press (1998).

1. Goto, S., Nishioka, T., and Kanehisa, M.; LIGAND: chemical database for enzyme reactions. Bioinformatics 14, 591-599 (1998). [9730924]
2. Goto, S., Nishioka, T., and Kanehisa, M.; LIGAND database for enzymes, compounds, and reactions. Nucleic Acids Res. 27, 377-379 (1999). [9847234]

Project Team

• Project Leader: Minoru Kanehisa
• Database Team: Susumu Goto, Hiroyuki Ogata, Hiroko Ishida, Sanae Asanuma, Kana Matsumoto, Toshi Nakatani, Nobue Takeuchi, Tomoko Deno, Megumi Yamaguchi, Ayumi Inoue
• Programming Team: Kazushige Sato, Wataru Fujibuchi, Tomomi Kamiya, Yoshiko Kimura, Kayo Okamoto, Yasuko Okada
• Curators: Takaaki Nishioka (metabolism), Kentaro Tomii (membrane transport), Hidemasa Bono, Atshuhiro Oka (signal transduction), Toshiaki Katayama (cell cycle), Masahiro Hattori (cell death), Yoshinobu Igarashi (cell-cell communication), Shuichi Kawashima (development), Park Keun-joon (nuclear transport), Keiko Takemoto (operon)

Acknowledgments

The KEGG project is supported by the grant-in-aid for scientific research on the priority area "Genome Science" from the Ministry of Education, Science, Sports and Culture of Japan. An additional support for system development is given by the Human Genome Center of the University of Tokyo. The computational resources are given by the Supercomputer Laboratory of the Institute for Chemical Research, Kyoto University.

Last updated: January 4, 1999

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