[HOME],
[START]
BioFinder Kategorien Suche
Molekularbiologie < Biologie
Weitere Unterkategorien:
Links in dieser Kategorie:
- Acid Alpha-Glucosidase Gene (Gaa)
- Amyloid precursor protein (APP)
- AMS Analytical micro Analytical micro-Systems: devices and chemicals for bioanalytics, material scien
Analytical micro-Systems (Regensburg, Germany) We offer devices and chemicals for bioanalytics, material science, biophysics: SPR spectrometer, impedance analyzer, functionalized alkylthiols; coating of gold electrodes by stable organic compounds for further immobilization of biomolecules
- ANCIENT PROTEINS, ANCIENT PATTERNS
Caudal genes are expressed in posterior cells in both vertebrate and insect early embryos, suggesting that they have a highly conserved role in pattern formation. Antibodies against the C. elegans Caudal homolog pal-1 first detect PAL-1 in the posterior blastomeres EMS and P2 in four-cell embryos. Staining through the 28-cell stage is limited to EMS and P2 progeny. In contrast, pal-1 mRNA appears to be present in all the cells in early embryos. This is very interesting because in Drosophila a posterior gradient of Caudal protein is generated from uniformly distributed mRNA. Thus it is possible that similar mechanisms control early Caudal expression patterns in both cellular C. elegans embryos and syncytial Drosophila embryos. To ask how pal-1 is regulated we have begun to examine PAL-1 expression in mutants defective in early patterning. PAL-1 expression in EMS and P2 is dependent on the par genes but is not dependent on mex-1, which is required for the asymmetric expression of skn-1. This indicates that there are multiple mechanisms for generating asymmetric expression patterns in early embryos. We have also found that pal-1(null) embryos from mosaic mothers that lack pal-1 in the germline die earlier with more severe defects than embryos from heterozygous mothers (previously examined by Edgar & Wood), suggesting a requirement for the maternally expressed pal-1 product.
- Angiotensin-converting enzyme (ACE)
- Angiotensinogen
- Apo E
- ApoA-I
- ApoC-III
- Apolipoprotein A-IV
- Arbeitsgruppen für strukturelle Molekularbiologie der Max-Planck-Gesellschaft
- Bakteriorhodopsin
Der lichtgetriebene Protonenpumpmechanismus des Bakteriorhodopsin wurde mit vielen verschiedenen Methoden untersucht, die dazu beitrugen, daß es heute eine detaillierte Vorstellung über die Struktur und den molekularen Mechanismus dieses Membranproteins gibt
- BiLaTec Bilatec GmbH
Purification/ Isolation of Nucleic Acids, Sample Preparation, Plastic Disposables, Electroelution, PCR and Services in Molecular Biology
- Biochemistry and Molecular Biology
- biomedpage Biomedpage - Resources in molecular biology and biomedicine
Biomedpage is a resource collection in biomedicine and molecular biology. Detailled descriptions of methods for molecular biology research techniques included.
- Biomedpage Biomedpage- Die wissenschaftliche Resourcensammlung für die Molekularbiologie un
Methodensammlungen, Kostenfreie Datenbankrecherche und eine umfangreiche Sammlung nützlicher Links zu den Bereichen Hefe Two-Hybrid Systeme, C. elegans Genetik, Molekularbiologie und Bioanalytik
- BIOTECH GmbH BioTechnologieZentrum Hennigsdorf
Technologie- und Gründerzentrum für humanmedizinische Biotechnologie mit diagnostischen und therapeutischen Schwerpunkten. Kooperation mit B.R.A.H.M.S Diagnostica GmbH. Start into market Services. Existenzgründung Biotechnologie Forschung B.R.A.H.M.S Vertrieb Diagnostik Investition Förderung
- BMERC BioMolecular Engineering Research Center
- CD2
- CD3 eta/phi
- Cell & Molecular Biology Online
- CRABPI
- CySPID Cytoskeletal Protein Interactions Database
- SFB189 Differenzierung und Regulation energiewandelnder biologischer Systeme
- Differing Roles for Zinc Fingers in DNA Recognition:Structure of
a Six-finger Tr
Abstract The crystal struture of the six NH2-terminal zinc fingers of Xenopus laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA gene promoter has been determined at 3.1 A resolution. Individual zinc fingers are positioned differently in the major groove and across the minor groove of DNA to span the entire length of the duplex. These results show how TFIIIA can recognize several separated DNA sequences by using fewer fingers than necessary for continuous winding in the major groove.
- Electrostatic surface potential of the HMG-1 box
The surface potential of the second HMG-1 box from rat HMG-1 is shown below. The majority of negatively-charged surfaces (shown in red) are located towards the bottom of the model, while there are several basic surfaces (shown in blue) on the opposing, concave surface. The conserved, positively-charged lysine and arginine residues flanked by prolines at positions 2 and 3 may be responsible for anchoring the DNA onto the concave surface of the protein. In addition, it has been proposed for human SRY that Ile 9 interacts with DNA through partial sidechain intercalation in the minor groove (King & Weiss, 1993).
- Energy scaffolds for HMG-1 box proteins
Energy scaffolds generated for models of selected HMG-1 proteins are shown below. These proteins, which contain all the elements of the HMG-1 box signature, have a well-packed domain that is held together mostly by hydrophobic interactions. These interactions involve most of the hydrophobic residues found in alpha-helices 1 and 2 within the HMG-1 box (Weir et al., 1993).
- Energy scaffolds for non-HMG proteins able to assume the shape of the HMG-1 box
In these proteins, strong pairwise interaction energies (< -1 kcal/mol) are observed for all 11 of the critical HMG-1 box residues involved in maintaining the three-dimensional structure of the domain. Homology model building experiments indicate that these proteins all give a statistically significant match of sequence to structure despite not containing the HMG-1 box signature.
- EMBL European Molecular Biology Laboratory, Heidelberg
- Forschungsstelle Enzymologie der Proteinfaltung der Max-Planck-Gesellschaft
- Fos B
- Gene Discovery
One goal of CGAP is to discover new human genes that may be useful in understanding the process of cancer or in monitoring its course. This process involves preparation of cDNA libraries from normal and cancer tissues, sequencing of randomly-selected cDNA clones, and classification of sequences into groups corresponding to known genes or putative novel genes. Current progress in gene discovery is summarized in the table below.
- GENE KNOCKOUTS WHICH PRIMARILY AFFECT THE CARDIOVASCULAR SYSTEM
- GkBB Gesellschaft f. klin. Biologie u. Bioanalytik
Hompepage der GkBB mit Informationen, Aktivitäten und Hintergründen zum klinischen Biologen
- Graduiertenkolleg Biosynthese d. Proteine u. Regulation ihrer Aktivität
- Graduiertenkolleg Funktionelle Proteindomänen, Bonn
- Graduiertenkolleg Membranproteine, Münster
Membranproteine: Signalerkennung, Signaltransfer und Stofftransport
- Graduiertenkolleg Molekularbiol. Analyse pathophysiol. Prozesse
- Graduiertenkolleg Regulation des Zellwachstums, Würzburg
- GRK120 Graduiertenkolleg Signalketten in lebenden Systemen, Berlin
- Harvard Dept of MCB
- Harvard University, Dept of Molcular and Cellular Biology
- SFB351 Hormonresistenz: Biochemie und Klinik, Düsseldorf
- IL-2
- Immage Library of Biological Macromolecules, Jena
- WIT Interactive Metabolic Reconstruction
- Interdisziplinärer Forschungsverbund Strukturbiologie, Berlin
- SFB474 Intrazelluläre Organisation von Regulations- und Transportprozessen
- IPK Gatersleben: Mansfeld-Server: IPK Projects
Welcome to the Mansfeld Server of the IPK Gatersleben: IPK Projects
- L14 S-type lectin
- Laboratory of Molecular Biology
Robert M. Bock Laboratories, University of Wisconsin
- Lecithin: cholosterol acyltransferase (LCAT)
- SFB197 Lipidorganisation u. Lipid-Protein-Wechselwirkungen in Bio- u. Modellmembranen
- Low density lipoprotein receptor
- MDL Max-Delbrück-Laboratorium in der Max-Planck-Gesellschaft
four independent research groups, which work on the following molecular biological a nd genetic topics: Protein Biogenesis and Localization (Nils Johnsson) as well as the mechanisms of transcriptional repression (Norbert Lehming) are being examinated in yeast, whereas Arabidopsis thaliana serves as a model system for the study of p lant signal transduction pathways (Klaus Palme) and the analysis of a plant genome (Renate Schmidt)
- Max-Planck-Institut für Infektionsbiologie
- MPI marine Mikrobiol Max-Planck-Institut für marine Mikrobiologie
Das Max-Planck-Institut für marine Mikrobiologie in Bremen wurde 1992 gegründet und beschäftigt sich mit Stoffumsetzungen in marinen Ökosystemen
- Methoden für die Mol Methoden und Resourcen in Molekularbiologie und Biomedizin
Die wissenschaftliche Info-Seite für die Bereiche Molekularbiologie und Biomedizin mit umfangreicher molekularbiologischer Methodensammlung, biologischen Internet-Links, Zugang zu Datenbanken, Laborprotokollen und kostenfreiem Medline-Zugang Die Seite ist bilingual gestaltet (Deutsch / English)
- Molecular Biology Places of Interest (BBSRC)
Link list.
- Molecular Biology Resource
- Molecular Neuroscience at Caltech
- SFB352 Molekulare Mechanismen intrazellulärer Transportprozesse
- SFB503 Molekulare und zelluläre Mediatoren exogener Noxen, Düsseldorf
- SFB399 Molekularpathologie der Proliferation, Saarland
- Mologen
Our areas of competence are gene expression, gene therapy and bioinformatics. We are dedicated to the development of DNA expression and delivery technologies for human and veterinary applications, leading to products for gene therapy, and prophylactic and therapeutic DNA-based vaccines.
- SFB506 Onkotherapeutische Nukleinsäuren, FU Berlin
- SFB353 Pathobiologie der Schmerzentstehung und Schmerzverarbeitung
- Pedro's BioMolecular Reasearch Tools (Uni. Düsseldorf)
- Plant Peroxidases
- Prions
Not just for mad cows.
- Project Goals
Our goal is to fully dissect the regulatory circuitry of the yeast genome by analyzing the genome-wide effects of mutations in all factors involved in transcription of protein-coding genes. The initial aim of the study is to determine the requirement for key components of the general transcriptional machinery which is recruited to promoters of protein coding genes.
- Protein Family Links
- Regulation of Gene Expression
Our work focuses on the apparatus responsible for gene expression and genome-wide regulatory circuitry. We have identified RNA polymerase II holoenzymes in yeast and in mammalian cells which we believe are responsible for initiation of transcription of most class II genes.
- SFB266 Regulation Phasengrenzschichten durch Makromoleküle u. Molekülaggregate
(Regulation der Organisation und Funktion synthetischer und biologischer Phasengrenzschichten ...)
- Renin Ren-1d
- Sites for the Molecular Biology - LINKS
- SFB394 SFB509 Sonderforschungsbereiche der Ruhr-Universität Bochum
- Structure of murine polyomavirus complexed with an
oligosaccharide receptor frag
- Structure of Structure I(KAPPA)B(ALPHA) / NF-(KAPPA)B
Complex
Abstract The file 1nfi.pdb contains the coordinates for the complex of p65 (rel homology region) / p50 (c-terminal domain of rel homology region) and IkB-alpha (ank repeat domain). The asymmetric unit contains two complexes - both are included in the file. One complex consists of chains A(p65)/B(p50C)/F(IkBa) and the other is C(p65)/D(p50)/E(IkBa). The N-terminal domains of p65 are not well ordered (especially the chain C p65N domain). Our paper is due out in Cell Dec. 11th
- Structure of the NF-KappaB p50 homodimer bound to DNA
Abstract The structure of a large fragment of the p50 subunit of the human transcription factor NF-KB, bound as a homodimer to DNA, reveals that the Rel-homology region has two beta-barrel domains that grip DNA in the major groove. Both domains contact the DNA backbone. The amino-terminal specificity domain contains a recognition loop that interacts with DNA bases; the carboxy-terminal dimerization domain bears the site of I-KappaB interaction. The folds of these domains are related to immunoglobulin-like modules. The amino terminal domain also resembles the core domain of p53.
- SFB169 Struktur und Funktion membranständiger Proteine, Frankfurt
- Targeting pal-1 translation to posterior blastomeres
The C. elegans pal-1 gene encodes a caudal homolog that specifies posterior blastomere identity. pal-1 activity is targeted to specific blastomeres by multiple regulatory steps. The first step is to repress translation of maternal pal-1 mRNA in oocytes and early embryos. Then, at the 4-cell stage, pal-1 translation is specifically derepressed in the two posterior blastomeres. The repression and derepression of pal-1 translation is controlled, at least in part, by the pal-1 3'UTR. Injected lacZ RNA that includes the pal-1 3' UTR is preferentially expressed in posterior blastomeres.
- TCR delta
- TENASCIN-C
- TGF-beta 1
- THE ACTIVITY OF THE C. ELEGANS CAUDAL HOMOLOG,
pal-1, IS SEQUENTIALLY RESTRICTED
The pal-1 protein is homologous to the caudal family of homeodomain proteins. caudal genes are expressed in posterior body regions in all animals examined and function to pattern the posterior body region of Drosophila and mouse. We have found that the pal-1 protein is first detected at the 4-cell stage in the two posterior blastomeres EMS and P2 (Hunter and Kenyon, submitted). However, analysis of embryos from pal-1(-) germline mosaic hermaphrodites shows that pal-1 function is required in only the somatic P2 descendants C and D. These observations raise two questions: How is the pal-1 protein localized to EMS and P2 and how is pal-1 function restricted to P2NULL
- The C. elegans CDC42 Homologue is Required for Zygotic
Polarity and is Distribut
The C. elegans zygote divides asymmetrically producing a large anterior and a small posterior blastomere. These two cells and their descendants express different blastomere specification proteins and produce different cell types. Genetic screens have identified six par genes that are required to polarize the zygote and early blastomeres. In addition, three of the PAR proteins have been shown to be asymmetrically localized in the zygote. However, the direct targets of the PARproteins are unknown. The par genes may act to organize cytoskeletal components that then function to segregate regulatory molecules or the PAR proteins may be targets of the cytoskeleton.
- The envelope glycoprotein from tick-borne encephalitis virus at
2Å resolution
Abstract The crystallographically determined structure of a soluble fragment from the major envelope protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a direction that would be parallel to the viral membrane. Residues that influence binding of monoclonal antibodies lie on the outward-facing surface of the protein. The clustering of mutations that affect virulence in various flaviviruses indicates a possible receptor binding site and, together with other mutational and biochemical data, suggests a picture for the fusion-activating, conformational change triggered by low pH.
- THE MATERNAL par GENES AND THE SEGREGATION OF
CELL FATE SPECIFICATION PATHWAYS I
The maternal par genes are required in the early C. elegans embryo to establish or maintain cellular and embryonic polarity. Mutations in the par genes disrupt many visible asymmetries and affect the subsequent patterning of cell fates. However, little is known about how mutations in the par genes affect the patterning of cell fates in the early embryo. To better define requirements for the genes par-1, par-2, par-3 and par-4, we analyzed the expression patterns of the maternal genes mex-3, pal-1, and skn-1, and we analyzed the requirements for these genes, as well as glp-1, for the specification of pharynx, intestine, and body wall muscle in par mutant embryos. In wild-type embryos, MEX-3 and GLP-1 are preferentially localized to anterior blastomeres at the 4-cell stage, while SKN-1 and PAL-1 are present only in posterior blastomeres. As inactivation of each par gene results in a unique phenotype with respect to the localization and function of these different cell fate specification molecules and pathways, we suggest that in some cases the par genes act independently of each other to control the patterning of cell fates.
- Thomas Schmidt-Glenewinkel
Research Interest: Biochemistry and Molecular Biology of Neurotransmitter Receptors and Ion Channels in Drosophila Melanogaster
- Three-dimensional structure of the tyrosine kinase c-Src
Abstract The structure of a large fragment of the c-Src tyrosine kinase, comprising the regulatory and kinase domains and the carboxy-terminal tail, has been determined at 1.7 Å resolution in a closed, inactive state. Interactions among domains, stabilized by binding of the phosphorylated tail to the SH2 domain, lock the molecule in a conformation that simultaneously disrupts the kinase active site and sequesters the binding surfaces of the SH2 and SH3 domains. The structure shows how appropriate cellular signals, or transforming mutations in v-Src, could break these interactions to produce an open, active kinase.
- transmembrane proteins
- trendenz trendenz
trendenz neues aus Forschung und Wissenschaft
- University of California, Section of Molecular and Cellular Biology
- Universität Bielefeld, Zellphysiologie
- Universität Bonn, Molekularbiologie
- vav
- Vimentin
- Virtual Library: Biological Molecules
- Biologe.de www.Biologe.de_Die Seite für biologisch relevante Informationen,Wörterbücher,Ref
Die Seite für biologisch relevante Informationen.Biologie,Biologen,Biologische Fachbücher,Bücher vergünstigt,Wörterbücher,Benutzer.dic,Studienplatztausch,Praktikumsbörse,Eselsbrücken,Lernhilfen,Universitäten,Unis,Studium,Referate,Methoden,Skripte, ,Diplom,Biologische Datenbanken,Sequenzen,DNA,Praktikant,Genetik,Botanik,Biochemie,Mikrobiologie,Neurologie,Neurogenetik,Neuroprothetik,Neurobionik,Bionik,Biowissenschaften,Biophysik,Neurowissenschaften,Fachschaften,Institute,Student,Zelle,Biotech,Verbände
- SFB388 Zelluläre Funktionen dynamischer Proteinwechselwirkungen, Freiburg
- Ökologie, Biotechnologie, Gentechnik, Ernährungsforschung, Pflanzenschutz
Populärwissenschaftliches Wissenschaftsmagazin mit Themen aus den Bereichen Agrarökologie, Pflanzenschutz, Biotechnologie, Gentechnik, Fischereiforschung, Ernährungsforschung etc. Der Bezug ist kostenlos.
© 2000 by Kurt Stüber