ENTRY       EC 6.3.5.5
NAME        Carbamoyl-phosphate synthase (glutamine-hydrolysing)
            Carbamoyl-phosphate synthetase (glutamine-hydrolysing)
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Carbon--nitrogen ligases with glutamine as amido-N-donor
SYSNAME     Carbon-dioxide:L-glutamine amido-ligase (ADP-forming,
            carbamate-phosphorylating)
REACTION    2 ATP + L-Glutamine + CO2 + H2O = 2 ADP + Orthophosphate +
            L-Glutamate + Carbamoyl phosphate
SUBSTRATE   ATP
            L-Glutamine
            CO2
            H2O
PRODUCT     ADP
            Orthophosphate
            L-Glutamate
            Carbamoyl phosphate
COMMENT     Formerly EC 2.7.2.9.
            Glutamine amidotransferase domian (type G) has SH protease-
            like catalytic residues.
PATHWAY     PATH: MAP00251  Glutamate metabolism
DISEASE     MIM: 114010  CAD trifunctional protein of pyrimidine biosynthesis
MOTIF       PS: PS00097  F-x-[EK]-x-S-[GT]-R-T
            PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QE]-x-[LIVMFA]
            PS: PS00482  D-[LIVMFYWSP]-H-[LIV]-H-[LIVF]-[RN]-x-[PG]
            PS: PS00483  [GA]-[ST]-D-x-A-P-H-x(4)-K
            PS: PS00866  [FYV]-P-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-x(3)-
                         [SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
GENES       MJA: MJ1019(carA) MJ1378 MJ1381
            MTH: MTH996 MTH997 MTH998
            ECO: b0032(carA) b0033(carB)
            HPY: HP0919 HP1237
            BSU: carA(cpa) carB(cpa) pyrAA pyrAB
            SYN: sll0370(carB) sll1498(carA)
            SCE: YJL130C(URA2) YJR109C(CPA2) YOR303W(CPA1)
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.5.5
            WIT (What Is There) Metabolic Reconstruction: 6.3.5.5
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