ENTRY       EC 6.3.4.6
NAME        Urea carboxylase
            Urease (ATP-hydrolysing)
            Urea carboxylase (hydrolysing)
            ATP--urea amidolyase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Urea:carbon-dioxide ligase (ADP-forming)
REACTION    ATP + Urea + CO2 = ADP + Orthophosphate + Urea-1-carboxylate
SUBSTRATE   ATP
            Urea
            CO2
PRODUCT     ADP
            Orthophosphate
            Urea-1-carboxylate
COFACTOR    Biotin
COMMENT     A biotinyl-protein. The yeast enzyme (but not that from green
            algae) also catalyses the reaction of EC 3.5.1.54, thus bringing
            about the hydrolysis of urea to CO2 and NH3.  Previously also
            listed as EC 3.5.1.45.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00910  Nitrogen metabolism
MOTIF       PS: PS00188  [GN]-[DEQ]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMA]-
                         x(3)-[LIVM]-x-[SA]
            PS: PS00866  [FYV]-P-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-x(3)-
                         [SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.4.6
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.6
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