ENTRY       EC 6.3.4.4
NAME        Adenylosuccinate synthase
            IMP--aspartate ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     IMP:L-aspartate ligase (GDP-forming)
REACTION    GTP + IMP + L-Aspartate = GDP + Orthophosphate +
            N6-(1,2-Dicarboxyethyl)-AMP
SUBSTRATE   GTP
            IMP
            L-Aspartate
PRODUCT     GDP
            Orthophosphate
            N6-(1,2-Dicarboxyethyl)-AMP
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00252  Alanine and Aspartate metabolism
DISEASE     MIM: 103060  Adenylosuccinate synthetase (Ade(-)H-complementing)
MOTIF       PS: PS00513  G-I-[GR]-P-x-Y-x(2)-K-x(2)-R
GENES       MJA: MJ0561(purA)
            MTH: MTH615
            ECO: b4177(purA)
            HIN: HI1633(purA)
            HPY: HP0255(purA)
            BSU: purA
            SYN: sll1823(purA)
            SCE: YNL220W(ADE12)
            HSA: ADSS
STRUCTURES  PDB: 1GIM  1ADE  1ADI  1GIN  1HON  1HOO  1HOP  1JUY  
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.4.4
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.4
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