ENTRY EC 6.3.4.3
NAME Formate--tetrahydrofolate ligase
Formyltetrahydrofolate synthetase
CLASS Ligases
Forming carbon-nitrogen bonds
Other carbon--nitrogen ligases
SYSNAME Formate:tetrahydrofolate ligase (ADP-forming)
REACTION ATP + Formate + Tetrahydrofolate = ADP + Orthophosphate +
10-Formyltetrahydrofolate
SUBSTRATE ATP
Formate
Tetrahydrofolate
PRODUCT ADP
Orthophosphate
10-Formyltetrahydrofolate
COMMENT In eukaryotes occurs as a trifunctional enzyme also having
methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) and
methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) activity.
PATHWAY PATH: MAP00630 Glyoxylate and dicarboxylate metabolism
PATH: MAP00670 One carbon pool by folate
PATH: MAP00790 Folate biosynthesis
DISEASE MIM: 172460 5,10-methylenetetrahydrofolate dehydrogenase,
MOTIF PS: PS00721 G-[LIVM]-K-G-G-A-A-G-G-G-Y
PS: PS00722 V-A-T-V-R-A-L-K-x-[HN]-G-G
PS: PS00766 [EQ]-x-E-[LIVM](2)-x(2)-[LIVM]-x(2)-[LIVM]-N-x-D-x(5)-
[LIVMF](3)-Q-L-P-[LV]
PS: PS00767 P-G-G-V-G-P-[MF]-T-V
GENES SCE: YBR084W(MIS1) YGR204W(ADE3)
HSA: MTHFD(MTHFC)
DBLINKS University of Geneva ENZYME DATA BANK: 6.3.4.3
WIT (What Is There) Metabolic Reconstruction: 6.3.4.3
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