ENTRY       EC 6.3.1.2
NAME        Glutamate--ammonia ligase
            Glutamine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
SYSNAME     L-Glutamate:ammonia ligase (ADP-forming)
REACTION    ATP + L-Glutamate + NH3 = ADP + Orthophosphate + L-Glutamine
SUBSTRATE   ATP
            L-Glutamate
            NH3
            4-Methylene-L-glutamate
PRODUCT     ADP
            Orthophosphate
            L-Glutamine
INHIBITOR   L-Methionine sulfoximine
            L-2-Amino-4-(hydroxymethylphosphinyl)butanoate
            2S,5S-Methionine sulfoximine
            3-(Phosphoacetylamido)-L-alanine
COMMENT     Also acts, more slowly, on 4-methylene-L-glutamate (cf.
            EC 6.3.1.7).
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00550  Peptideglycan biosynthesis
            PATH: MAP00910  Nitrogen metabolism
DISEASE     MIM: 138290  Glutamate-ammonia ligase (glutamine synthase)
MOTIF       PS: PS00180  [FYWL]-D-G-S-S-x(6,8)-[DENQSTAK]-[SA]-[DE]-x(2)-
                         [LIVMFY]
            PS: PS00181  K-P-[LIVMFYA]-x(3,5)-[NPAT]-G-[GSTAN]-G-x-H-x(3)-S
            PS: PS00182  K-[LIVM]-x(5)-[LIVMA]-D-[RK]-[DN]-[LI]-Y
GENES       MJA: MJ1346(glnA)
            MTH: MTH1570
            ECO: b3870(glnA)
            HIN: HI0865(glnA)
            HPY: HP0512(glnA)
            BSU: glnA
            SYN: slr0288(glnN) slr1756(glnA)
            SCE: YPR035W(GLN1)
            HSA: GLUL(GLNS)
STRUCTURES  PDB: 1LGR  2GLS  2LGS  
DBLINKS     University of Geneva ENZYME DATA BANK: 6.3.1.2
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.2
            SCOP (Structural Classificaion of Proteins): 6.3.1.2
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