ENTRY EC 6.2.1.3
NAME Long-chain-fatty-acid--CoA ligase
Acyl-CoA synthetase
Fatty acid thiokinase (long chain)
Acyl-activating enzyme
Palmitoyl-CoA synthase
Lignoceroyl-CoA synthase
Arachidonyl-CoA synthetase
CLASS Ligases
Forming carbon-sulfur bonds
Acid--thiol ligases
SYSNAME Acid:CoA ligase (AMP-forming)
REACTION ATP + a Long-chain carboxylic acid + CoA = AMP + Pyrophosphate +
an Acyl-CoA
SUBSTRATE ATP
Long-chain carboxylic acid
Fatty acid
CoA
PRODUCT AMP
Pyrophosphate
Acyl-CoA
COFACTOR Magnesium
COMMENT Acts on a wide range of long-chain saturated and unsaturated
fatty acids, but the enzymes from different tissues show some
variation in specificity. The liver enzyme acts on acids from
C6 to C20; that from brain shows high activity up to C24.
PATHWAY PATH: MAP00071 Fatty acid metabolism
DISEASE MIM: 152425 Fatty-acid-Coenzyme A ligase, long chain 1
MIM: 152426 Fatty-acid-Coenzyme A ligase, long-chain 2
MOTIF PS: PS00455 [LIVMFY]-x(2)-[STG](2)-G-[ST]-[STEI]-[SG]-x-[PASLIVM]-K
GENES MTH: MTH657
ECO: b1805(fadD)
HIN: HI0002 HI0389B(fadD)
BSU: acsA lcfA yhfL yhfT
SYN: slr1609
SCE: YER015W(FAA2) YIL009W(FAA3) YMR246W(FAA4) YOR317W(FAA1)
HSA: FACL1(Hs.89549) FACL2(FACL1)
DBLINKS University of Geneva ENZYME DATA BANK: 6.2.1.3
WIT (What Is There) Metabolic Reconstruction: 6.2.1.3
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