ENTRY EC 6.2.1.23
NAME Dicarboxylate--CoA ligase
Carboxylyl-CoA synthetase
CLASS Ligases
Forming carbon-sulfur bonds
Acid--thiol ligases
SYSNAME omega-Dicarboxylate:CoA ligase (AMP-forming)
REACTION ATP + an alpha(omega)-Dicarboxylic acid = AMP + Pyrophosphate +
an omega-Carboxyacyl-CoA
SUBSTRATE ATP
alpha(omega)-Dicarboxylic acid
Dodecanedioic acid
PRODUCT AMP
Pyrophosphate
omega-Carboxyacyl-CoA
COMMENT Acts on dicarboxylic acids of chain length C5 to C16; the best
substrate is dodecanedioic acid.
DBLINKS University of Geneva ENZYME DATA BANK: 6.2.1.23
WIT (What Is There) Metabolic Reconstruction: 6.2.1.23
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