ENTRY       EC 6.1.1.4
NAME        Leucine--tRNA ligase
            Leucyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Leucine-tRNA(Leu) ligase (AMP-forming)
REACTION    ATP + L-Leucine + tRNA(Leu) = AMP + Pyrophosphate +
            L-Leucyl-tRNA(Leu)
SUBSTRATE   ATP
            L-Leucine
            tRNA(Leu)
PRODUCT     AMP
            Pyrophosphate
            L-Leucyl-tRNA(Leu)
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP01020  Protein biosynthesis (prokaryotes)
            PATH: MAP01030  Protein biosynthesis (eukaryotes)
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-G-
                         [HNTG]-[LIVMFYSTAGPC]
GENES       MJA: MJ0633
            MTH: MTH1508
            ECO: b0642(leuS)
            HIN: HI0921(leuS)
            HPY: HP1547(leuS)
            BSU: leuS
            MGE: MG266(leuS)
            MPN: F11_orf793o(leuS)
            SYN: sll1074(leuS)
            SCE: YLR382C(NAM2) YPL160W(CDC60)
            HSA: LARS
DBLINKS     University of Geneva ENZYME DATA BANK: 6.1.1.4
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.4
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