ENTRY       EC 5.4.2.4
NAME        Bisphosphoglycerate mutase
            Diphosphoglycerate mutase
            Glycerate phosphomutase
            Bisphosphoglycerate synthase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     3-Phospho-D-glycerate 1,2-phosphomutase
REACTION    3-Phospho-D-glyceroyl phosphate = 2,3-Bisphospho-D-glycerate;
            2,3-Bisphospho-D-glycerate + H2O = 3-Phospho-D-glycerate +
            Orthophosphate;
            2-Phospho-D-glycerate = 3-Phospho-D-glycerate
SUBSTRATE   3-Phospho-D-glyceroyl phosphate
            2,3-Bisphospho-D-glycerate
            H2O
            2-Phospho-D-glycerate
PRODUCT     2,3-Bisphospho-D-glycerate
            3-Phospho-D-glycerate
            Orthophosphate
COMMENT     In the direction shown, this enzyme is phosphorylated by
            3-phosphoglyceroyl phosphate to give phosphoenzyme and
            3-phosphoglycerate. The latter is rephosphorylated by the enzyme
            to yield 2,3-bisphosphoglycerate, but this reaction is slowed by
            dissociation of 3-phosphoglycerate from the enzyme, which is
            therefore more active in the persence of added 3-phosphoglycerate.
            This enzyme also catalyses, slowly, the reactions of EC 3.1.3.13
            and 5.4.2.1.
            Formerly EC 2.7.5.4.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
DISEASE     MIM: 172250  Phosphoglycerate mutase A, nonmuscle form
            MIM: 222800  2,3-bisphosphoglycerate mutase; Hemolytic anemia due
                         to bisphosphoglycerate mutase deficiency (1)
            MIM: 261670  Phosphoglycerate mutase, muscle form; Myopathy due to
                         phosphoglycerate mutase deficiency (3)
MOTIF       PS: PS00175  [LIVM]-x-R-H-G-[EQ]-x(3)-N
GENES       HSA: BPGM(Hs.79537)
DBLINKS     University of Geneva ENZYME DATA BANK: 5.4.2.4
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.4
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